General
Preferred name
BI-4916
Synonyms
P&D ID
PD127506
CAS
2244451-48-5
Tags
available
free of charge
probe
Probe info
Probe type
experimental probe
Probe sources
High-quality chemical probes
opnMe Portal
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study[1][2][3].
PRICE 950
DESCRIPTION BI-4916 is a selective phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces the migration of cancer cells.BI-4916 can be used in the study of cancer and metabolic diseases.
DESCRIPTION BI-4916 is an ester prodrug of the highly potent PHGDH inhibitor BI-4924, which shows good selectivity against the majority of other dehydrogenases. The prodrug BI-4916, in contrast to BI-4924, is cell permeable and is hydrolysed in cells to BI-4924. Therefore BI-4916 was used to achieve intracellular enrichment of BI-4916. We also provide the negative control BI-5583. The ester prodrug BI-4916 should be used to perform cellular experiments. (opnMe Portal)
Compound Sets
4
CZ-OPENSCREEN Bioactive Library
High-quality chemical probes
PD127506
MedChem Express Bioactive Compound Library
HY-126253
opnMe Portal
phgdh-inhibitor-bi-4916
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
526.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
3.59
TPSA
114.7
Fraction CSP3
0.3
Chiral centers
1.0
Largest ring
6.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Phosphoglycerate Dehydrogenase (PHGDH)
PHGDH
Pathway
Metabolic Enzyme/Protease
Source data